Forbidden Pill

A very rare consumable dropped exclusively by the Spewer boss that temporarily enhances all your active abilities. The wiki warns there will be permanent consequences for taking it — the exact nature of those consequences is not fully documented, but the risk-reward framing suggests something lasting and significant. Use it when you need a serious power spike and can live with whatever comes after.

Very rare rarity combined with boss-only acquisition means the Forbidden Pill is one of the rarest consumables in the game. The temporary ability enhancement applies broadly to all active abilities, giving a generalized power spike rather than targeting a single ability. The permanent consequence may be a stat penalty, a debuff, a mutation, or something structural to your build — the "forbidden" framing implies it's meaningfully costly.

Best saved for a critical encounter where you need maximum ability output, such as a difficult boss fight or a gauntlet of consecutive enemies. Don't use it casually — the permanent downside means you should understand your run well enough to know you can handle the consequence. If your build is already fragile or near a breaking point, the aftermath may end the run faster than it saves it.