Tiny Tumor

Tiny Tumor is a 4 HP small enemy spawned by Mother set items — appearing at the start of battle and respawning each time one is killed. Its CancerMelee attack permanently reduces the target's Constitution by 1 per hit and has a chance to inflict the Cancer status. Unlike most minion enemies, Tiny Tumor's threat compounds over time: Constitution drain is permanent for the run, meaning repeated hits across multiple fights accumulate into serious long-term HP reduction for affected cats.

With 2 Strength and 2 Speed it is slow and weak individually, but the Mother set spawns it continuously throughout the run — not just in a single fight. Any cat that gets hit repeatedly by Tiny Tumors will see their maximum HP shrink over the course of a run. The Cancer status it can apply adds further persistent damage on top of the stat drain.

Kill Tiny Tumors before they can land hits — their 4 HP means any attack eliminates them instantly. Avoid sending low-Constitution cats into melee with them first. Because they continually respawn from Mother equipment, factor the cumulative Constitution drain into whether equipping the Mother set on a fragile cat is worth it over a long run. AoE abilities that clear them at the start of a fight before they can take an action are ideal.