Distemper

Distemper is a progressive disease disorder that permanently modifies your cat's combat stats after each battle. At the end of every battle, you gain +10% crit chance, +25% crit damage, and +5% miss chance permanently. Over multiple battles, the crit bonuses stack to create devastating critical hits, but the miss chance accumulation gradually makes the cat less reliable at landing attacks.

Distemper is heritable and can pass from parent to kitten through breeding. It can also be acquired through events or applied with a Disorder Syringe from the Organ Grinder. After 10 battles, you would have +100% crit chance (always crit), +250% crit damage, and +50% miss chance. The escalating miss chance eventually means half your attacks miss, but the ones that land deal enormous critical damage.

Strategically, Distemper is exceptional when paired with The Shining (attacks cannot miss), which completely negates the miss chance accumulation while letting you keep the crit bonuses. Without The Shining, Distemper becomes progressively worse as the miss chance overwhelms the crit benefits. In short adventures with few battles, the crit gains outweigh the small miss penalty. In long adventures, the miss chance becomes crippling without accuracy support. The Shining plus Distemper is one of the most powerful disorder combinations in the game.