Overview
Guillotina is the first House Boss you encounter in Mewgenics, invading your home hub after you clear The Boneyard and progress into Act 2. She attacks in three separate escalating encounters, each one harder than the last. Unlike in-run bosses, Guillotina is fought exclusively by retired cats—cats that have already completed adventures and are living at your home. Defeating each encounter also rewards a unique quest item that unlocks new content including the path to the Throbbing Domain.
How to Prepare
After The Boneyard clear you receive a warning that Guillotina is approaching. You have limited in-game days to run adventures and level up multiple retired cats. Do not try to fight Guillotina with only one or two retired cats: she has too much HP and too many actions per turn to be handled solo. Aim for a full party of four retired cats with diverse class roles.
Phase 1: The Stomp (400 HP)
Guillotina starts with 400 HP, attacks frequently, and uses heavy frontal stomp attacks that deal splash damage to nearby cats. She uses a toss ability that can scatter your party across the arena. She has a swallow mechanic: she consumes one of your cats and that cat must flail from inside her to escape. Keep units spread out to reduce multi-target stomps, and use your healer to stabilise whoever gets swallowed.
Enrage at 50% HP
At roughly half health Guillotina enters an enrage state, healing a chunk of HP and becoming significantly more aggressive. This is the most dangerous window of Phase 1. Commit your strongest remaining abilities when she enrages to push through quickly.
Phase 2: Decapitation (Body 250 HP, Head 250 HP)
Guillotina’s body and severed head separate at the start of Phase 2. Each part has 250 HP and can act independently. The head is faster and more dangerous: it attacks in linear patterns that knock your cats back and deal heavy damage. The body is slower but hits harder up close. You can ignore the body and focus the head: when the head is destroyed, the body automatically loses 100 HP, effectively creating a health shortcut.
Phase 3: The Shriek (Critical)
In the final phase Guillotina’s body and severed head can reattach. If they successfully combine, she performs Shriek, which inflicts both Hex and Poison on all cats simultaneously. This is a devastating combination that can end the fight instantly if your party is already damaged. The primary goal of Phase 3 is to keep the head and body physically separated on the board. Assign one cat specifically to body-block or distract the body to keep it away from the head.
Recommended Composition
Thief: high mobility for backstabbing and disengaging, excellent for Phase 2 head targeting.
Hunter: safe ranged damage across all phases without needing to close distance.
Tank: absorbs Guillotina’s frontal attacks and prevents her from reaching squishier cats.
Cleric: mandatory for healing through the stomp, swallow, and phase-2 knockback damage.
Quest Item Rewards
Each Guillotina victory drops a unique quest item. Collecting all three from the three escalating fights unlocks the path to the Throbbing Domain. Winning these fights is therefore not just a combat milestone but a meta-progression requirement.