Overview
Guillotina is the first House Boss you encounter in Mewgenics, invading your home hub after you clear The Boneyard and progress into Act 2. She attacks in three separate escalating encounters, each one harder than the last. Unlike in-run bosses, Guillotina is fought exclusively by retired cats that have already completed adventures and are living at your home. Defeating each encounter rewards a unique quest item that unlocks new content, including the path to the Throbbing Domain.
How to Prepare
After The Boneyard clear you receive a warning that Guillotina is approaching. You have limited in-game days to run adventures and level up multiple retired cats. Do not try to fight Guillotina with only one or two retired cats: she has too much HP and too many actions per turn to be handled solo. Aim for a full party of four retired cats with diverse class roles.
Phase 1: The Stomp (400 HP)
Guillotina starts with 400 HP, 5 ATK, 3 SPD, and 5 LCK. She attacks frequently using heavy frontal stomp attacks that deal splash damage to nearby cats. She uses a toss ability that can scatter your party across the arena. Her Swallow mechanic lets her inhale a unit from up to 10 tiles away and consume them. Once swallowed, that cat must flail from inside her to escape. If she uses Digest, the swallowed cat is instantly killed and Guillotina recovers 25 HP. Keep units spread out to reduce multi-target stomps, and use damage-over-time effects like Bleed and Burn to whittle her high HP pool.
Enrage at 50% HP
At roughly half health Guillotina enters an enrage state, restoring 50 HP and gaining 100 max HP while becoming significantly more aggressive. This is the most dangerous window of Phase 1. Commit your strongest remaining abilities when she enrages to push through quickly.
Phase 2: Decapitation (Body 250 HP, Head 250 HP)
Guillotina's body and severed head separate at the start of Phase 2. The body has 250 HP, 8 ATK, and 1 SPD; the head has 250 HP, 4 ATK, and 5 SPD. The head is faster and more dangerous: it attacks in linear patterns that knock your cats back and deal heavy damage. The body is slower but hits harder up close. You can ignore the body and focus the head: when the head is destroyed, the body automatically loses 100 HP, effectively creating a health shortcut.
Phase 3: The Shriek (Critical)
In the final phase Guillotina's body and severed head can reattach. If they successfully combine, she performs Shriek, which inflicts both Hex and Poison on all cats simultaneously. This is a devastating combination that can end the fight instantly if your party is already damaged. The primary goal of Phase 3 is to keep the head and body physically separated on the board. Assign one cat specifically to body-block or distract the body to keep it away from the head.
Recommended Composition
Thief: high mobility for backstabbing and disengaging, excellent for Phase 2 head targeting.
Hunter: safe ranged damage across all phases without needing to close distance.
Tank: absorbs Guillotina's frontal attacks and prevents her from reaching squishier cats.
Cleric: mandatory for healing through the stomp, swallow, and Phase 2 knockback damage.
Quest Item Rewards
Each Guillotina victory drops a unique quest item. Collecting all three from the three escalating fights unlocks the path to the Throbbing Domain. Winning these fights is therefore not just a combat milestone but a meta-progression requirement.